Jan 3, 2014 · This month's cover highlights the article A split intein and split luciferase-coupled system for detecting protein-protein interactions by Igor Stagljar, Zhong Yao and colleagues. Peptide tags derived from tripartite NanoLuciferase are incorporated into the revised Split Intein-Mediated Protein Ligation assay (SIMPL2).

Jan 16, 2025 · This cover highlights the article Kinesin-like motor protein KIF23 maintains neural stem and progenitor cell pools in the developing cortex by Sharmin Naher, Takako Kikkawa, Noriko Osumi and colleagues. The image shows that GFP + Kif23 knockdown cells (green) precociously differentiate into neurons and migrate to the upper area in the embryonic cortex, suggesting a function of KIF23 in the ...

Jan 31, 2025 · The EMBO Journal publishes papers describing original research of broad general interest in molecular and cell biology - a particular emphasis is placed on molecular mechanism and physiological relevance. - Submit here EMBO Reports publishes long- and short-format papers that communicate a major ...

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Our immune system's daily routine is a constant battle against attacks by invading potential pathogens. With a complex network of different cells, receptors and signalling pathways, the immune system ensures the elimination of pathogens, non‐microbial foreign substances or damaged cells whilst also tolerating ‘self’ and commensal bacteria.

Dec 2, 2024 · This cover highlights the article Kinesin-like motor protein KIF23 maintains neural stem and progenitor cell pools in the developing cortex by Sharmin Naher, Takako Kikkawa, Noriko Osumi and colleagues. The image shows that GFP + Kif23 knockdown cells (green) precociously differentiate into neurons and migrate to the upper area in the embryonic cortex, suggesting a function of KIF23 in the ...

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Nov 19, 2024 · Legionella pneumophila encodes the largest arsenal of eukaryotic host-manipulating proteins, called effectors. Leveraging high-throughput structural prediction tools, coupled with in cellulo assays, revealed previously unrecognized functional and cryptic domains in L. pneumophila effectors.

Biosecurity. Planned research and results from experiments should be evaluated at an early stage for possible dual use concerns. In such cases, authors should first consult with an appropriate local body concerning the implications for biosecurity and public health.