Sep 25, 2022 · Immunohistochemistry is a laboratory test. Learn how IHC testing works to help diagnose cancer more precisely, what to expect, the benefits and risks.

Immunohistochemistry (IHC) allows pathologists to achieve something remarkable. It enables them to see signs of disease invisible to the naked eye. IHC uses your body’s powerful fighters, antibodies, to expose harmful, microscopic substances that cause disease.

IHC provides diagnostic guidance in approximately 90% of undifferentiated malignant tumours but usually at the end of a fastidious and expensive algorithm based on both morphology and IHC.

Experimentally, IHC can be employed to investigate the earliest changes in transformed tissues, identifying cellular changes not normally visible with H&E. Individual markers for proliferation, apoptosis, and specific tumor proteins can be used to help distinguish hyperplasia from neoplasia and determine specific tumor origin/type.

Apr 3, 2023 · Immunohistochemistry (IHC) is a widely used staining technique that allows doctors to detect certain cancers and infectious diseases more easily. Since its introduction in 1941, scientists have...

According to immunohistochemistry (IHC) visualized tumor markers such as enzymes, oncogenes, tumor-specific antigens, tumor suppressor genes and tumor proliferation markers, doctors can efficiently predict oncogenesis and diagnose a cancer as benign or malignant, determine the stage and the grade of a cancer.

IHC is widely used for diagnosis of cancers; specific tumor antigens are expressed de novo or up-regulated in certain cancers. This article deals with the various applications of IHC in diagnosis of diseases, with IHC playing an important role in diagnostic and research laboratories. KEY WORDS: Antibody, antigen, disease, immunohistochemistry.

Jun 23, 2016 · Traditionally, IHC analysis has been used for diagnosis in difficult cases, but more recently it has served as a prognostic or predictive marker, as a tool in the search for new therapeutic targets, and even in combination as a surrogate for molecular classifications and multigene prognostic panels.

Dec 13, 2024 · Immunohistochemistry (IHC) is an important technique for identifying tumor markers, which can provide valuable insights for cancer diagnosis, prognosis, and treatment planning....

Nov 25, 2024 · In oncology, IHC tests are particularly valuable for identifying tumor markers, proteins that are produced in higher amounts in cancer cells compared to normal cells. These markers help pathologists determine the origin of the cancer, its aggressiveness, and its likelihood to respond to certain treatments.