Tropomyosin receptor kinase A (TrkA), [5] also known as high affinity nerve growth factor receptor, neurotrophic tyrosine kinase receptor type 1, or TRK1-transforming tyrosine kinase …

The human TRKA gene divided into 17 exons ranged in size from 18 bases (exon 9) to 394 bases (exon 17), and 16 introns ranged in size from 170 bases (intron 9) to at least 3.3 kb (intron I).

Nov 18, 2015 · Presently, three human isoforms (TRKAI, TRKAII and TRKAIII) and two rat isoforms (TRKA L0 and TRKA L1) have been described. We show here that human TRKA …

TrkA and TrkB are 49% identical overall, with >76% sequence identity in the intracellular region. How can two homologous RTKs, both thought to engage similar downstream signaling …

Normal Trk receptors do not contain amino acid or DNA sequences related to tropomyosin. The three most common types of trk receptors are trkA, trkB, and trkC. Each of these receptor …

Feb 1, 2010 · NGF binds to at least two classes of receptors: tropomyosin receptor kinase A (TrkA), the high-affinity receptor, and p75NTR, the low affinity receptor (Fig. 41A.2). Both TrkA …

Nov 20, 2000 · NGF binds with high affinity to the extracellular region of a tyrosine kinase receptor, TrkA, which comprises three leucine-rich motifs (LRMs), flanked by two cysteine-rich …

In human sensory tissue, the majority of TRKA positive cells exhibits a size around 300-700 lm 2 , while TRKB positive cells peak around 1200-1600 lm 2 and TRKC positive cells around...

TrkA is a highly glycosylated protein. Therefore, its size can differ depending on the amount of glycosylation present. Un-glycosylated TrkA is 87 KDa, so this is likely what the 90kDa band is …

TRKA, TRKB and TRKC are transmembrane proteins that comprise the TRK receptor family. TRKA is encoded by the NTRK1 gene located on chromosome 1q21-q22 [2]. TRKB is …