Mutational cooperativity linked to combinatorial epigenetic gain …
Apr 13, 2015 · Specific combinations of acute myeloid leukemia (AML) disease alleles, including FLT3 and TET2 mutations, confer distinct biologic features and adverse outcome. We …
TET2 in Normal and Malignant Hematopoiesis - PMC
In AML, TET2 shows comutational patterns with NPM1, FLT3 and DNMT3a (Papaemmanuil et al. 2016). How these mutations cooperate in leukemogenesis remains an area of intense …
Combined heterozygosity of FLT3 ITD, TET2, and DNMT3A results …
Sep 8, 2022 · Heterozygous mutations in FLT3ITD, TET2, and DNMT3A are associated with hematologic malignancies in humans. In patients, cooccurrence of mutations in FLT3ITD …
TET2 mutation is an unfavorable prognostic factor in acute …
Oct 6, 2011 · TET2 mutation was a poor prognostic factor in patients with intermediate-risk cytogenetics, and a scoring system integrating TET2 mutation with FLT3-ITD, NPM1, and …
Driver mutations in acute myeloid leukemia - PMC
TET2 mutations co-occur with NPM1, FLT3-ITD, and DNMT3A, and largely mutually exclusive with IDH1/2 mutations . The majority of the evidence indicates that TET2 is an early event …
Emerging DNA Methylome Targets in FLT3-ITD-Positive Acute …
May 2, 2024 · Treatment of FLT3-ITD + /TET2-mutant and FLT3-ITD + /IDH2 R140Q double mutated mice models with quizartinib in combination with azacitidine or enasidenib, …
JCI Insight - Combined heterozygosity of FLT3ITD, TET2, and …
Sep 8, 2022 · In the current study, we have analyzed and compared the genetic, phenotypic, and transcriptomic features of AML driven by a combination of FLT3ITD TET2, FLT3ITD DNMT3A, …
Molecular Mechanisms of Resistance to FLT3 Inhibitors in Acute …
In this comprehensive review, we focus on molecular mechanisms underlying the development of resistance to relevant FLT3 inhibitors and elucidate how this knowledge might help to develop …
Landscape of TET2 mutations in acute myeloid leukemia
We investigated ten-eleven translocation 2 (TET2) mutations in acute myeloid leukemia (AML), their correlation with other gene mutations and prognostic value. By deep-sequencing, 131 …
Microenvironmental CXCL12 deletion enhances Flt3-ITD acute
Dec 22, 2022 · Fms-like tyrosine kinase 3 (Flt3) tyrosine kinase inhibitors (Flt3-TKI) have improved outcomes for patients with Flt3-mutated acute myeloid leukemia (AML) but are …
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