The Ras superfamily, derived from "Rat sarcoma virus", is a protein superfamily of small GTPases. [1] Members of the superfamily are divided into families and subfamilies based on their structure, sequence and function. The five main families are …

The Ras superfamily of small GTPases is a group of more than 150 small G proteins, all of which share some degree of homology to the founding member Ras. These small GTPases function as molecular switches within cells, impacting nearly all cellular processes.

The Ras superfamily is divided into five major families: Ras, Rho, Arf/Sar, Ran, and Rab. Members of the Ras family function as signaling nodes that are activated by diverse extracellular stimuli and that regulate intracellular signaling.

The Ras superfamily of small GTPases is composed of more than 150 members, which share a conserved structure and biochemical properties, acting as binary molecular switches turned on by binding GTP and off by hydrolyzing GTP to GDP.

Mar 1, 2005 · The Ras superfamily of small guanosine triphosphatases (GTPases) comprise over 150 human members (Table S1 in supplementary material), with evolutionarily conserved orthologs found in Drosophila, C. elegans, S. cerevisiae, S. pombe, Dictyostelium and plants (Colicelli, 2004).

Mar 1, 2005 · The Ras superfamily at a glance. The Ras superfamily at a glance. The Ras superfamily at a glance J Cell Sci. 2005 Mar 1;118(Pt 5):843-6. doi: 10.1242/jcs.01660. Authors Krister Wennerberg 1 , Kent L Rossman, Channing J …

Nov 24, 2010 · There is increasing evidence that the aberrant activity of numerous members of the Ras superfamily of small GTPases contributes to cancer growth, invasion and metastasis.

The Ras superfamily of small GTPases is a group of more than 150 small G proteins, all of which share some degree of homology to the founding member Ras. These small GTPases function as molecular switches within cells, impacting nearly all cellular processes.

The RAS superfamily of GTP (guanosine triphosphate) hydrolysis–coupled signal transduction relay proteins can be subclassified into RAS, RHO, RAB, and ARF families, as well as the closely related Gα family.

Jan 23, 2012 · The Ras superfamily is a fascinating example of functional diversification in the context of a preserved structural framework and a prototypic GTP binding site. Thanks to the availability of complete genome sequences of species representing important evolutionary branch points, we have analyzed the …