Mar 3, 2005 · We observed a correlation between immunoreactivity for p62 and Ki-67 LI in HCC. The tumors with a high p62 expression showed a significantly high cell growth fraction determined by the Ki-67 LI, indicating that p62 is one of the factors promoting cellular proliferation.

Abnormal cell proliferation appears to be a possible predictor of tumorigenesis, Ki-67 protein expression is closely related to the cell proliferation and could be used as a biomarker for the growth in the most of human tumors.

Sep 19, 2023 · The nuclear p62 expression was negatively correlated with ki67 expression (Figure 3 a; r = −0.321; p < 0.01). The expression of p62 in the cytoplasm positively correlated with ki67 expression (Figure 3 b; r = 0.353; p < 0.01) and XPO1 expression (Figure 3 c; r …

Feb 23, 2021 · A 54 year old woman recently received the diagnosis of invasive ductal carcinoma for a right breast mass. Which of the prognostic markers below, if more than 30%, suggests aggressive behavior of the tumor?

Ki-67 is an immunohistochemical marker of proliferating cells. Recent studies suggested that MYC and BCL2 protein co-expression is an independent indicator of poor prognosis in diffuse large B-cell lymphoma (19,20).

According to its predictive role, pKi67 expression identifies subpopulations of patients who are more likely to respond to a given therapy. The Ki67 labeling index is an independent prognostic factor for survival rate, which includes all stages and grade categories.

Ki-67 protein has been widely used as a proliferation marker for human tumor cells for decades. In recent studies, multiple molecular functions of this large protein have become better understood. Ki-67 has roles in both interphase and mitotic cells, and its cellular distribution dramatically changes during cell cycle progression.

Feb 7, 2019 · We confirmed that high levels of Ki 67 expression are significantly associated with high tumor grade; this indicates an increased proliferation of tumor cells, enhanced invasiveness, and faster growth.

Results: E-cadherin and Ki-67 expression levels show high association with tumor stage and grade (p<0.001), in contrast, the association with recurrence has proven insignificant. Patients with non-aberrant biomarker expression levels have much higher survival rates than the cases with aberrant expression.

According to its predictive role, pKi67 expression identifies subpopulations of patients who are more likely to respond to a given therapy. The Ki67 labeling index is an independent prognostic factor for survival rate, which includes all stages and grade categories.