Sep 10, 2023 · What does a low Ki-67 mean for breast cancer treatment? Each person with breast cancer needs an individualized treatment plan from their healthcare team. Overall, a low Ki-67 generally means a less aggressive cancer.

Ki-67 is a way to measure how fast the cancer cells are growing and dividing. Higher values for Ki-67 (typically over 30%) mean that many cells are dividing, so the cancer is likely to grow and spread more quickly.

Low Ki-67 expression was considered with scores of 0–14% (control group), and nine miRNAs were overexpressed in this group: miR-let-7a, miR-let-7b, miR-let-7e, miR-29a, miR-143, miR-181a, miR-214, miR-218, and small non-coding molecule, SNORD48.

Oct 23, 2024 · Hypoxia, or low oxygen levels, has been shown to stimulate the expression of KI-67, promoting tumor growth and progression. Inflammation, on the other hand, can lead to increased KI-67 expression through the activation of various signaling pathways.

Patients with Ki-67 higher than 15% exhibited higher incidence of metastasis and recurrence than those with Ki-67 less than 15% (P = 0.000). Conclusions: Ki-67 may be considered as a valuable biomarker in breast cancer patients.

Feb 20, 2025 · Generally speaking, Ki-67 levels over 14% to 25% are considered high (depending on breast cancer and biopsy type) whereas levels over 40% are considered very high. High Ki-67 has been linked to unfavorable breast cancer outcomes in numerous breast cancer studies.

Low Ki-67 scores, often ranging from 0% to 10%, suggest that the tumor is less proliferative. This is aligned with a better prognosis. Patients with low Ki-67 scores tend to have slower-growing tumors, which may respond favorably to hormone therapies.

Ki–67 index test. The Ki-67 or mitotic index are ways of describing how many cells are dividing. A specialist doctor (pathologist) counts the number of NEN cells that have started to divide into 2 new cells (mitoses) under a microscope. And a special stain measures the Ki-67 value.

Feb 23, 2021 · Used in surrogate immunohistochemical classification for gene expression profile based intrinsic breast cancer subtypes (low: luminal A; high: luminal B; higher: HER2; highest: basal-like) (Hoda: Rosen's Diagnosis of Breast Pathology …

Jan 31, 2024 · The Ki-67 test is used in breast cancer to measure the rate of cell proliferation or growth in tumor tissues. Measuring a specific protein associated with cancer cell growth may help determine...