The prognostic impact of FLT3 -ITD and NPM1 mutation in adult …
Mar 23, 2020 · In acute myeloid leukemia (AML) FLT3 internal tandem duplication (ITD) and nucleophosmin 1 (NPM1) mutations provide prognostic information with clinical relevance …
The Prognostic Impact of FLT3 in NPM1-Mutated AML: Co …
Nov 15, 2022 · While FLT3 internal tandem duplication (ITD) is known to confer worse prognosis even in the setting of NPM1 according to the recent European LeukemiaNet (ELN) 2022 …
Co-occurrence of FLT3-TKD and NPM1 mutations defines a highly …
Aug 17, 2017 · FLT3 -TKD/ NPM1 double mutation status is associated with superior relapse-free survival compared with NPM1 -only–mutated AML. Allogeneic stem cell transplant in complete …
NPM1 and FLT3-ITD/TKD Gene Mutations in Acute Myeloid …
Results: Nucleophosmin 1 (NPM1) and fms-like tyrosine kinase 3 (FLT3) mutations were seen in 22.8% and 16.3% of patients, respectively. Amongst FLT3 mutations, FLT3 -ITD mutation was …
The prognostic impact of FLT3-ITD and NPM1 mutations in …
Internal tandem duplication of the fms-like tyrosine kinase-3 gene (FLT3- ITD) and nucleophosmin-1 (NPM1) mutations have prognostic importance in acute myeloid leukemia …
Prognostic Relevance of NPM1 and FLT3 Mutations in Acute …
In acute myeloid leukemia, molecular genetics abnormalities, particularly NPM1 and FLT3 mutations, have a recognized prognostic role in the ELN risk classification and guide treatment …
Co-mutation landscape and its prognostic impact on newly …
Jul 22, 2024 · Approximately 25–35% of adult patients with acute myeloid leukemia (AML) carries NPM1 mutation, which generally indicated a favorable outcome in the absence of FLT3-ITD …
NPM1 and FLT3-ITD/TKD Gene Mutations in Acute Myeloid Leukemia
Jan 1, 2021 · Results: Nucleophosmin 1 (NPM1) and fms-like tyrosine kinase 3 (FLT3) mutations were seen in 22.8% and 16.3% of patients, respectively. Amongst FLT3 mutations, FLT3 -ITD …
FLT3 mutated acute myeloid leukemia: 2021 treatment algorithm
May 27, 2021 · Approximately 30% of patients with newly diagnosed acute myeloid leukemia (AML) harbor mutations in the fms-like tyrosine kinase 3 (FLT3) gene. While the adverse …
Identification of FLT3 and NPM1 Mutations in Patients with Acute ...
Our study aims to develop a cost effective and comprehensive in-house conventional PCR method for detection of FLT3 - ITD, FLT3-D835 and NPM1 mutations and to evaluate the …
- Some results have been removed