Fibroblast growth factor 21 (FGF21) is a potent regulator of lipid and glucose metabolism. In this study, we tested the hypothesis that recombinant FGF21 (rFGF21) administration may reduce …

Sep 1, 2018 · Blood-brain barrier (BBB) disruption and dysfunction result in brain edema, which is responsible for more than half of all deaths after severe traumatic brain injury (TBI). Fibroblast …

The pharmacokinetics of the interactions of FGF21 with the BBB could have direct therapeutic implications for this recently discovered peptide. Therefore, we quantified the influx of intact …

Dec 4, 2023 · The current study revealed four main findings; (a) for ICH patients, the serum level of FGF21 is positively correlated with the Δ GCS%; (b) FGF21 can alleviate neural disorders …

Here, we tested the hypothesis that rFGF21 protects against poststroke blood–brain barrier (BBB) damage in T2DM mice via peroxisome proliferator-activated receptor gamma (PPARγ) …

Fibroblast growth factor 21 (FGF21) is a potent regulator of lipid and glucose metabolism. In this study we tested the hypothesis that recombinant FGF21 (rFGF21) administration may reduce …

Oct 3, 2023 · Fibroblast growth factor 21 (FGF21) has been shown to be a potent neuroprotective agent that reduces neuroinflammation and protects against BBB leakage. In this study, we …

In mice, we found that FGF21 treatment is capable of alleviating BBB damage, mitigating brain edema, reducing lesion volume and improving neurofunction after ICH. In vitro, after …

Dec 4, 2023 · We provide the first evidence that FGF21 is capable of protecting the BBB after ICH by improving SIRT6-mediated mitochondrial homeostasis.

Dec 1, 2007 · The pharmacokinetics of the interactions of FGF21 with the BBB could have direct therapeutic implications for this recently discovered peptide. Therefore, we quantified the influx …