Loop diuretics are a powerful type of diuretic that work by inhibiting the sodium-potassium-chloride (Na+/K+/2Cl) co-transporter in the thick ascending loop of Henle (hence the name loop diuretic), which is located in the kidneys.

Loop diuretics act on the Na +-K +-2Cl − symporter (NKCC2) in the thick ascending limb of the loop of Henle to inhibit sodium, chloride and potassium reabsorption. This is achieved by competing for the Cl − binding site. Loop diuretics also inhibit NKCC2 at macula densa, reducing sodium transported into

Loop diuretics are medications used to treat fluid overload conditions such as heart failure, nephrotic syndrome or cirrhosis, and hypertension, in addition to edema. Learn about side effects, drug names, and uses.

May 22, 2023 · Loop diuretics are medications used in the management and treatment of fluid overload conditions such as heart failure, nephrotic syndrome or cirrhosis, and hypertension, in addition to edema. This activity reviews the indications, action, and contraindications for loop diuretics as a valuable agent in managing fluid overload and hypertension.

Mar 11, 2024 · There are three main types of diuretic: Loop diuretics (for example, furosemide). Thiazide diuretics (for example, bendroflumethiazide). These are mainly used for treating high blood pressure (hypertension) and fluid on the legs (oedema). Potassium-sparing diuretics.

Furosemide is the most commonly used loop diuretics. Some other examples are bumetanide, torsemide and ethacrynic acid. They primarily act on thick ascending limb of loop of Henle. They inhibit a protein called Na + /K + /2Cl – transporter which is responsible for sodium, potassium and chloride transport.

Review Diuretics in the treatment of hypertension. Part 2: loop diuretics and potassium-sparing agents. [Expert Opin Pharmacother. 2014] Tamargo J, Segura J, Ruilope LM. Expert Opin Pharmacother. 2014 Apr; 15 (5):605-21. Epub 2014 Jan 23. Review Piretanide: a loop-active diuretic. Pharmacology, therapeutic efficacy and adverse effects.

Loop diuretics, including furosemide, bumetanide, and torsemide, act primarily on the thick ascending limb of the loop of Henle. This segment plays a critical role in urinary concentration, as it is impermeable to water.

Mar 17, 2022 · Loop diuretics are a class of medications used to cause diuresis, or increased urine flow. They differ from other types of diuretics in how they increase urine production. Other diuretic classes include thiazide diuretics, carbonic anhydrase inhibitors, and …

Jan 28, 2025 · Loop diuretics are a group of diuretic medications primarily used to treat fluid overload in edematous conditions such as heart failure and cirrhosis. Loop diuretics also treat hypertension, but not as a 1st-line agent.