Nov 18, 2023 · In this review paper, we provide an overview of the recent advancements in the computational, mathematical, and statistical modelling of hSCs, with particular focus on applications in regenerative medicine within ophthalmology.

Mar 4, 2025 · The stem cell treatment for blinding cornea injuries — called cultivated autologous limbal epithelial cells, or CALEC — was developed at Mass Eye and Ear. It consists of removing stem cells from a healthy eye with a biopsy, expanding them into a cellular tissue graft in a novel manufacturing process that takes two to three weeks, and then ...

Sep 13, 2021 · Over the past decade, the California Institute for Regenerative Medicine (CIRM) has funded and supported the translation, from early research concepts to human trials, of therapeutic stem cell approaches for dry age-related macular degeneration, retinitis pigmentosa, and limbal stem cell deficiency.

Jul 1, 2015 · In gene therapy, a specific gene is delivered via a viral vector; in stem cell therapy, whole cells are infused or transplanted into a patient. Both approaches are being investigated for the treatment of inherited and acquired diseases.

Main outcome measures: The primary end points were the safety and tolerability of hESC-derived RPE cell administration. We also investigated evidence of the survival of transplanted cells and measured retinal structure and function using microperimetry and spectral-domain OCT.

Mar 4, 2025 · An expanded clinical trial that tested a groundbreaking, experimental stem cell treatment for blinding cornea injuries found the treatment was feasible and safe in 14 patients who were treated and followed for 18 months, and there was a high proportion of complete or partial success. The results of this new phase 1/2 trial are published in ...

Aug 1, 2023 · Modern animal trials have also evaluated the efficacy of stem cells in the optic nerve and retinal pathologies. This chapter briefly overviews stem cell-based therapy in ophthalmology, discussing in-depth the fascinating and evolving therapeutic options reported in …

Feb 24, 2012 · trabecular meshwork cells may be divided into endothelial cells, juxtacanalicular cells, and Schlemm’s canal cells, although the relationsh ips between these anatomical distinctions is Stem ...

Mar 4, 2025 · We developed a two-stage manufacturing process utilizing cultivated autologous limbal epithelial cells (CALEC), the first xenobiotic-free, serum-free, antibiotic-free protocol developed in the ...

Jan 6, 2025 · Currently, stem cell therapy for ophthalmopathy involves various cell types, such as embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), mesenchymal stem cells (MSCs), and...