Jan 21, 2025 · Our research demonstrated that HP1α, HP1β, and HP1γ facilitate the positioning of ATRX within the mitotic centromere area through their interaction with the first two [P/L]-X-V …

Jun 12, 2011 · The ADD domain in ATRX is now found to form a new histone H3 recognition module with binding being promoted by H3K9me3 and antagonized by H4K4me3.

ATRX associates with HP1 [63,65,99] via the conserved pentapeptide HP1-interacting motif Pro-Xaa-Val-Xaa-Leu (PxVxL) [51,100], that allows ATRX and HP1 colocalization within PCH …

Taken together, our findings indicate that HP1 ensures appropriate ATRX localization at the mitotic centromere, hence safeguarding centromeric cohesion and preventing chromosomal …

Aug 6, 2018 · In animals, the network of proteins interacting with HP1 is mainly associated with constitutive heterochromatin marked by H3K9me3. HP1 physically interacts with the putative …

By coimmunofluorescence, ATRX localizes with a mouse homologue of the Drosophila heterochromatic protein HP1 in vivo, consistent with a previous two-hybrid screen identifying …

May 6, 2020 · Here, we investigate the RNA binding function of ATRX, a chromatin remodeler with roles in silencing of repetitive regions of the genome and in recruitment of the polycomb …

Aug 30, 2017 · ATRX accumulates in nuclear foci and is required for therapy-induced senescence in multiple types of transformed cells exposed to either DNA damaging agents or CDK4 …

inked (ATRX) serves as a part of the sucrose nonfermenting 2 (SNF2) chromatin-remodeling complex. In interphase, ATRX localizes to pericentromeric heterochr.

Aug 6, 2018 · In this study, we show that the Arabidopsis thaliana ortholog of ATRX participates in H3.3 deposition and possesses specific conserved domains in plants. We found that plant Like …