Feb 12, 2024 · Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a progressive, paralytic, neurodegenerative disease affecting the upper and lower motor neurons. ALS is the most common motor neuron disease (MND) and has both sporadic and familial forms.

The present review will provide an overview of key advances in the understanding of ALS pathophysiology and diagnosis, focusing on the importance of cortical hyperexcitability and its relationship to advances in genetic and molecular processes implicated in ALS pathogenesis.

Apr 10, 2024 · Amyotrophic lateral sclerosis (a-my-o-TROE-fik LAT-ur-ul skluh-ROE-sis), known as ALS, is a nervous system disease that affects nerve cells in the brain and spinal cord. ALS causes loss of muscle control.

In this review, different aspects of ALS are discussed, including epidemiology, aetiology, pathogenesis, clinical features, differential diagnosis, investigations, treatment and future prospects. Keywords: amyotrophic lateral sclerosis, sporadic and familial ALS, TDP‐43 pathology.

Apr 17, 2023 · Amyotrophic lateral sclerosis (ALS) is a chronic, progressive neurologic disease characterized by degeneration of upper and lower motor neurons in the central nervous system

Sep 15, 2024 · This review offers an in-depth examination of amyotrophic lateral sclerosis (ALS), addressing its epidemiology, pathophysiology, clinical presentation, diagnostic techniques, and current as well as emerging treatments.

Disease mechanisms (i.e. the process of ALS disease) help define causes of ALS. Researchers from all over the world are working to better understand ALS disease mechanisms. ALS is a heterogeneous disease, meaning that there are many diverse ways that disease can occur.

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by the progressive loss of corticospinal and lower motor neurons (MNs) in brain, brainstem, and spinal cord.

May 9, 2012 · Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by death of pyramidal neurons in the motor cortex (upper motor neurons) and motor neurons in the brain stem and central spinal cord (lower motor neurons).

Amyotrophic lateral sclerosis (ALS) is a fatal paralytic neurodegenerative disorder of unknown cause, mainly characterized by a progressive loss of motor neurons in the cerebral cortex, brainstem, and spinal cord.