SciELO27d
Simultaneous LC-MS/MS Determination of Sacubitril, Valsartan and LBQ657 in Human Plasma and Its Application to Clinical Study
The mixture was vortexed for 10 min, followed by centrifugation at 2,500 g for 10 min. An aliquot of 100 μL supernatant was transferred to another clean 96-well plate containing 100 μL ...
eLife1y
Binding and sequestration of poison frog alkaloids by a plasma globulin
Alkaloids are important bioactive molecules throughout the natural world, and in many animals they serve as a source of chemical defense against predation. Dendrobatid poison frogs bioaccumulate ...
Frontiers2y
Molecular Characterization Analysis of Prevalent Infectious Bronchitis Virus and Pathogenicity Assessment of Recombination Strain in China
Avian coronavirus infectious bronchitis virus (IBV) is a respiratory pathogen of chickens, resulting in severe economic losses in the poultry industry. This study aimed to monitor and isolate the ...
eLife4y
PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response
It is being increasingly appreciated that the immunomodulatory functions of PARP1 inhibitors (PARPi) underlie their clinical activities in various BRCA-mutated tumors. PARPi possess both PARP1 ...