This study provides a potentially useful investigation into the positive role of BDNF/TrkB signaling in implanted dental pulp stem cells to enhance dentin regeneration in the context of dental caries.

2006). NGF acts on a low-affinity p75 receptor and a high-affinity tropomyosin-related kinase receptor A (TrkA) (Pincelli and Marconi, 2000). In summary, recent literature has indicated that KCs are ...

Like most plasma membrane proteins, type I interferon (IFN) receptor (IFNAR) traffics from the outer surface to the inner compartments of the cell. Long considered as a passive means to simply control ...

They have the potential to bind to particular Trk receptors with high affinity and p75NTR with low affinity. This is done to evoke neurotrophic or pro-apoptotic signaling. NGF binds to TrkA ...

Through binding to and activating their cognate receptors (NGF to TrkA, BDNF and NT4 to TrkB, NT3 predominantly to TrkC), neurotrophins promote neuronal survival, axonal growth and target field ...

The mechanisms that account for the positive actions are not well understood. Here we report that GCs can selectively activate Trk receptor tyrosine kinases after in vivo administration in the brain ...