How cardiac cell fates are specified during heart development remains elusive. This study identifies a level-dependent role ...

This progression corresponded to decreased collagen density, lowered numbers of SMA + fibroblasts and downregulation of the transforming growth factor beta (TGF-β)/SMAD signalling pathway in FAK ...

It has recently been shown that the anticholinergic tiotropium may suppress TGF-β1-induced Smad2/4 activation in lung fibroblasts suggesting a crosstalk between TGF-β1 and muscarinic signalling.35 In ...

In contrast, another downstream effecter of TGF-β/Smad signaling pathway, Smad2, exerts its renal protective role by counter-regulating the Smad3. Furthermore, recent studies demonstrated that Smad3 ...

The manuscript presents valuable data suggesting that enalapril elevates pSmad1/5/9 signaling, reduces cellular senescence, and enhances physiological functions in aged mice. However, the in vivo ...

Under ASX rules large investors and investment funds must disclose when they own more than a 5% stake in Tribeca Global Natural Resources Limited (TGF). However, you won't necessarily see their names ...

Cilomilast also inhibited the activation of TGF-β1-Smad2/3 signaling in TGF-β1-treated fibroblast cells. Conclusion: The findings of this study suggest that cilomilast is protective against renal ...

Here we use a combination of structural biology, genome editing, and biochemistry to show that SGS mutations in SKI abolish its binding to phosphorylated SMAD2 and SMAD3. This results in stabilization ...