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A predictive biophysical model that integrates protein-DNA structures and sequences to accurately determine genomic binding sites and affinities of DNA-binding proteins.
For decades, sequence-to-sequence alignment is a crucial tool in bioinformatics that identifies the similarity between a query and the reference genome sequence. Because one single reference sequence ...
Sequence alignments are often used to analyze genomic data. However, such alignments are often only calculated and compared on small sequence intervals for analysis purposes. When comparing longer ...
A simple statistical test shows that contrary to current practice, the 'gaps' within DNA protein and sequence alignments commonly used in evolutionary biology can provide important information ...
The six assemblies were integrated into a multiassembly graph with minigraph. We only considered autosomal sequences because the haplotype-resolved assemblies represent either paternal or maternal ...
After years of development, the complexity of the biological sequence alignment algorithm is gradually increasing, and the lack of high abstract level domain research leads to the complexity of its ...
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