Each of our trillions of cells bustles with activity in a carefully choreographed quest to keep us healthy. At their core, quality control mechanisms ensure that the right proteins are in the right ...
Figure 1. Cartoon displaying the different regulators of TPC2 function. Rab7a enhances TPC2 activity while TMEM63a/b (OCaR1/2) reduce TPC2 activity. ATP blocks TPC2 through mTOR. JPT2 or Lsm12 mediate ...
The chloride-proton exchanger CLC-7 plays critical roles in lysosomal homeostasis and bone regeneration and its mutation can lead to osteopetrosis, lysosomal storage disease and neurological disorders ...
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