C&EN25d
Discovery of 5-Phenylthiazol-2-amine Derivatives as Novel PI4KIIIβ Inhibitors with Efficacious Antitumor Activity by Inhibiting the PI3K/AKT Axis
State Key Laboratory of Natural Medicines, Department of Organic Chemistry, China Pharmaceutical University, Nanjing 210009, China ...
Frontiers27d
Quality Matters? The Involvement of Mitochondrial Quality Control in Cardiovascular Disease
The ULK-1 complex regulates the nucleation and phagophore formation process through the recruitment of VPS34 and the formation of PI3P. PI3P then contributes to the phagophore formation through the ...
eLife1mon
Drug Discovery: How to exploit the recycling system of a cell
Each of our trillions of cells bustles with activity in a carefully choreographed quest to keep us healthy. At their core, quality control mechanisms ensure that the right proteins are in the right ...
Frontiers4y
Autophagy and Cancer Dormancy
Among the upstream signaling pathways regulating autophagy, inhibition of the PI3K/AKT pathway emerges as a common observation. In many reports, mTOR pathway that is downstream to AKT was shown to be ...
eLife6y
Reciprocal regulation among TRPV1 channels and phosphoinositide 3-kinase in response to nerve growth factor
NGF activates phosphoinositide 3-kinase (PI3K), the enzyme that generates PI(3,4)P 2 and PIP 3, and PI3K activity is required for sensitization. One tantalizing hint came from the finding that the ...