Adding metformin to letrozole and abemaciclib (Verzenio) was tied to deep responses and prolonged progression-free survival (PFS) in some patients with recurrent estrogen receptor (ER)-positive ...

Professor Peter Garland CBE, who served as Chief Executive of the ICR from 1989 to 1999, passed away on 5 March. He also played an important role as the Chair of Cambridge Antibody Technology (CAT) ...

State Key Laboratory of Natural Medicines, Department of Organic Chemistry, China Pharmaceutical University, Nanjing 210009, China ...

New York, USA, Feb. 25, 2025 (GLOBE NEWSWIRE) -- LAG-3 Immunotherapies Market Set for Rapid Growth in the Coming 10 Years Across the 7MM as Next-Generation Therapies Advance | DelveInsight The LAG ...

Functional analyses support that this mutation specifically impairs Nef`s ability to stimulate PI3K/Akt/mTORC2 signalling. This important study suggests that the accessory viral protein Nef impairs B ...

Numerous studies have confirmed that the activation of phosphatidylinositol 3-kinase (PI3K)/AKT signaling promotes the proliferation, migration, and glycolysis of HCC cells, and is a widely studied ...

Several pieces of evidence indicate that Akt acts downstream of PI3K to regulate HCN2. First, Akti and PI-103 had nearly identical effects on HCN2, reducing current magnitude and shifting its ...

NGF activates phosphoinositide 3-kinase (PI3K), the enzyme that generates PI(3,4)P 2 and PIP 3, and PI3K activity is required for sensitization. One tantalizing hint came from the finding that the ...