State Key Laboratory of Natural Medicines, Department of Organic Chemistry, China Pharmaceutical University, Nanjing 210009, China ...

elegans. Recent studies have revealed that autophagy gene cascades act downstream of IIS, targeting the target of the rapamycin (TOR) signaling pathway as well as mTOR and its downstream effector S6K, ...

6 NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Sandwell and West Birmingham NHS Foundation Trust & Institute of ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. m 6 A RNA modification has been linked to ...

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As the PI3K pathway is important for many normal cellular ... of downregulation of phosphorylation of proteins, including p70 S6K, and functionally in terms of cell proliferation.

Nutrition in early life has profound effects on an organism, altering processes such as organogenesis. However, little is known about how specific nutrients affect neuronal development. Dendrites of ...

PI3K, phosphoinositide3-kinase; PVDF, polyvinylidene fluoride; S6K I, ribosomal protein S6 kinase polypeptide I; TBS-T, Tris-buffered saline Tween; TUNEL, terminal deoxynucleotidyl ...

And how does ZNRF2 affect acidity within the lysosomes? Mechanistic target of rapamycin (mTOR) is a conserved serine/threonine protein kinase of the phosphatidylinositol 3-kinase (PI3K)-related kinase ...