C&EN25d
Discovery of 5-Phenylthiazol-2-amine Derivatives as Novel PI4KIIIβ Inhibitors with Efficacious Antitumor Activity by Inhibiting the PI3K/AKT Axis
State Key Laboratory of Natural Medicines, Department of Organic Chemistry, China Pharmaceutical University, Nanjing 210009, China ...
BMJ27d
Phosphatidylinositol 3-kinase delta pathway: a novel therapeutic target for Sjögren’s syndrome
6 NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Sandwell and West Birmingham NHS Foundation Trust & Institute of ...
Nature1mon
Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery
Two chemical inhibitors have been used to probe the function of PI3K: wortmannin, a fungal metabolite that irreversibly inhibits p110 by reacting covalently with the catalytic site 5, and the ...
eLife1mon
SIV-specific neutralizing antibody induction following selection of a PI3K drive-attenuated nef variant
Functional analyses support that this mutation specifically impairs Nef`s ability to stimulate PI3K/Akt/mTORC2 signalling. This important study suggests that the accessory viral protein Nef impairs B ...
GitHub1y
piVCCU is a project to install the original Homematic CCU3 firmware inside a virtualized container (lxc) on ARM based single board computers.
Banana Pi M1 running Armbian with Mainline kernel (LEDs of RPI-RF-MOD not supported due to incompatible GPIO pin header) Banana Pi Pro running Armbian with Mainline kernel Libre Computer AML-S905X-CC ...
Frontiers1y
Toll-like receptors in cardiac hypertrophy
Toll-like receptors (TLRs) are a family of pattern recognition receptors (PRRs) that can identify pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). TLRs ...
Frontiers2y
Vasoactive intestinal peptide–VIPR2 signaling regulates tumor cell migration
Gain-of-function mutations in PI3K (i.e., mutations in the p110 catalytic subunit of PI3K) enhance the PI(3,4,5)P 3 signaling pathway and are frequently found in breast cancers and other cancers (9, ...
eLife6y
Reciprocal regulation among TRPV1 channels and phosphoinositide 3-kinase in response to nerve growth factor
NGF activates phosphoinositide 3-kinase (PI3K), the enzyme that generates PI(3,4)P 2 and PIP 3, and PI3K activity is required for sensitization. One tantalizing hint came from the finding that the ...