C&EN25d
Discovery of 5-Phenylthiazol-2-amine Derivatives as Novel PI4KIIIβ Inhibitors with Efficacious Antitumor Activity by Inhibiting the PI3K/AKT Axis
State Key Laboratory of Natural Medicines, Department of Organic Chemistry, China Pharmaceutical University, Nanjing 210009, China ...
The Globe and Mail1mon
IA Financial has a war chest for more acquisitions after flurry of deals led to a boom in assets under management
IA Financial IAG-T chief executive Denis Ricard is on the hunt for more acquisitions with $1.4-billion of capital at the ready, as he looks to boost the company’s U.S. insurance operations as ...
Nature1mon
Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery
The phosphatidylinositol-3-kinase (PI3K) pathway plays a crucial role in cell growth and survival and is activated in various cancers. Multiple components of the pathway are frequently targeted by ...
Investopedia2mon
How AI Is Used in Business
AI is having a significant impact on the business world, affecting jobs, workers, firms, and industries Elysse Bell is a finance and business writer for Investopedia. She writes about small ...
Frontiers2y
The dual role of the CD95 and CD95L signaling pathway in glioblastoma
Figure 4 The PI3K-AKT signaling pathway mediated by CD95. CD95 induces the c-YES/calcium/PI3K pathway and c-YES/EGFR/PI3K pathway to mediate cell migration. Tumor migration and invasion can also be ...
Frontiers4y
Regulation of HCN2 Current by PI3K/Akt Signaling
Several pieces of evidence indicate that Akt acts downstream of PI3K to regulate HCN2. First, Akti and PI-103 had nearly identical effects on HCN2, reducing current magnitude and shifting its ...
eLife6y
Reciprocal regulation among TRPV1 channels and phosphoinositide 3-kinase in response to nerve growth factor
NGF activates phosphoinositide 3-kinase (PI3K), the enzyme that generates PI(3,4)P 2 and PIP 3, and PI3K activity is required for sensitization. One tantalizing hint came from the finding that the ...
eLife7y
Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells
By monitoring single-cell dynamics in each of these contexts, we identified PI3K/Akt regulation of glycolysis as a multifaceted modulator of single-cell metabolic dynamics that is required to maintain ...