1 Data reported in press release of March 25, 2024; mean increase of 326% in six-hour urinary sodium excretion at 3 months follow up vs baseline, and 95% reduction of loop diuretics over same period.

Research shows that high intakes of dietary magnesium, an essential mineral for our health, may help lower blood pressure.

However, early on, loop diuretics seemed to inherit the perceived metabolic effects of hydrochlorothiazide (Toivonen and Mustala, 1966). This concern may have originated from a 1959 study that first ...

Estrogen therapy is linked to increased risks of BCC, cSCC, and cM, with higher doses correlating with greater risk. Loop diuretics and thiazide diuretics are associated with increased risks of ...

Diuretic resistance can be countered by combination therapy. 2 For instance, adding a thiazide to a loop diuretic suppresses NaCl transport in the TAL, PCT and DCT. 7 Likewise, adding ...

Exploratory Expanded Endpoint In FINEARTS-HF, there were 1,250 patients who required oral diuretic intensification in an outpatient clinic, 664 who experienced a first HF hospitalization, and 87 who ...

Taken together, our three pNKCC1/loop diuretics co-structures revealed two modes of NKCCs inhibition by loop diuretic drugs: the carboxyl group-bearing furosemide and bumetanide exhibit K + -dependent ...

Na + –K + –Cl − cotransporters functions as an anion importers, regulating trans-epithelial chloride secretion, cell volume, and renal salt reabsorption. Loop diuretics, including furosemide, ...

CHICAGO, IL—A novel way of taking the loop diuretic bumetanide—by nasal spray—is safe and well tolerated in healthy adults, according to preliminary randomized data. Diuretic concentrations achieved ...

Quick Takes In a prespecified analysis of the STEP-HFpEF program, semaglutide use compared to placebo was associated with improvement in health status, weight loss, BNP levels, and exercise function ...