Novo Nordisk has signed a deal worth up to $1bn with Lexicon Pharmaceuticals for the exclusive global rights to LX9851, an ...

We present a one-step, visible light-induced synthesis of bicyclo[1.1.1]pentane-ketone, a bioisostere for benzoyl groups that ...

Here, the authors report the structure-guided engineering of thermostable AOS from Thermus thermophilus to expand the range of amino acids and simplify N-acetylcysteamine acyl-thioester substrates.

Since the 1990s, medicinal chemistry research has demonstrated that replacing benzene rings with bicyclo[1.1.1]pentane derivatives enhances drug ...

We had the arch. We just needed a new slogan for it. The city built the original Reno Arch in 1926 to celebrate the completion of the transcontinental highways: the Lincoln Highway and Victory ...

These phospholipid acyl chains determine the viscosity of the membrane, which in turn influences many crucial membrane-associated functions, such as the passive permeability of hydrophobic ...

Department of Chemistry, School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan 430070, China ...

Ryder lives with a rare genetic condition, Very long-chain acyl-coenzyme A dehydrogenase deficiency (VLCAD). The condition prevents her body from processing fats into energy, leaving Ryder ...

Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, United States ...

The N-acyl amino acids are a family of bioactive lipids with pleiotropic physiologic functions, including in energy homeostasis. Their endogenous levels are regulated by an extracellular mammalian ...

In this study, we demonstrate that the mitochondrial acyl carrier protein (ACP), which has a well-known role in FASII, plays an unexpected and evolutionarily conserved role in FeS biogenesis. ACP is a ...

ACS indicates acyl-CoA synthetase; ATGL, adipose triglyceride lipase gene; FATP1, fatty acid transport protein 1; DAGT, diacylglycerol acyl transferase; LpL, lipoprotein lipase. Because of the ...