The team tackled a critical challenge in treating multiple myeloma—a blood cancer where malignant plasma cells accumulate in bone marrow, leading to debilitating bone lesions in 80% of patients.

The incurable bone marrow cancer “multiple myeloma” often develops unnoticed in the bone marrow over decades. In advanced stages, lesions form that can destroy the bone and spread to other parts of ...

A research team from the Heidelberg Medical Faculty, the German Cancer Research Center (DKFZ), the Berlin Institute of Health ...

Bone disease is a hallmark of multiple myeloma (MM), associated with bone ... It correlates with quality of life and survival. Osteolytic bone lesions are the result of excessive bone resorption ...

When blood cancer cells break through the bone and multiply, tumor cells become dangerously diverse and the immune response in the region changes, researchers report. The detailed insights into cancer ...

People are living longer, living better with multiple myeloma. But I think for the vast majority of people who are diagnosed, we still don't have a curative treatment for multiple myeloma, so that, to ...

During a Case-Based Roundtable® event, Muhammad Umair Mushtaq, MD, discussed managing long-term toxicity concerns related to ...

More information: Raphael Lutz et al, Bone marrow breakout lesions act as key sites for tumor-immune cell diversification in multiple myeloma, Science Immunology (2025). DOI: 10.1126/sciimmunol ...

[141] Bone disease is a hallmark of multiple myeloma (MM), associated with bone ... Osteolytic bone lesions are the result of excessive bone resorption due to increased osteoclast formation ...