A decades-old TB vaccine turned cancer therapy may unlock new immunotherapies by reprogramming immune cell development in the bone marrow.

Researchers identified a natural 'brake' within the innate immune system: the inhibitory receptor Siglec-E (SigE) and its human counterparts, Siglec-7 and Siglec-9. This receptor helps ...

Innate Pharma SA (Euronext Paris: IPH; Nasdaq: IPHA) (“ Innate ” or the “ Company ”) today announces a €14,999,998.59 capital increase subscribed by Sanofi.

The researchers were especially concerned about recipients developing cytokine release syndrome, a life-threatening condition that is caused by the recipient immune system overreacting to cell therapy ...

In this cross-journal Collection, we invite research into the complex signalling pathways of innate immunity, emphasising the activation and regulation of pattern recognition receptors in response ...

The innate immune system recognizes broad molecular patterns, such as molecules that certain RNA viruses generate as they replicate. It is often the first line of defense against a threat, but the ...

Clinical research has long focused on ways to harness the actions of the immune system. From vaccines to immunotherapies, researchers have used their knowledge of the immune system to develop ...

Synedgen’s Multivalent Innate Immune Signaling Target (MIIST) platform targets receptors in the glycocalyx, a key to human innate immunity. Historically an underappreciated target in drug development, ...

Toll-like receptors (TLR) are phylogenetically conserved mediators of innate immunity that are essential for establishing adaptive immune responses against invading pathogens. TLR7 is an endosomal ...

Effect of cholesterol restriction on antiviral innate immunity in vivo The mouse genome also encodes noncanonical type I IFN genes, although the IFN-ω gene is not conserved. In bone-marrow-derived ...

The Duke Human Vaccine Institute is developing a new vaccine targeting the H5N1 avian flu virus that can respond to various strains of the virus and provide long-lasting immunity.