In patients with heart failure with preserved ejection fraction and obesity, tirzepatide improved clinical outcomes compared ...

Chronic Kidney Disease (CKD) indicates prolonged kidney damage over three months, often undetectable until significant harm occurs. Key risk factors include diabetes, high blood pressure, and obesity.

4 Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) is the most widely used formula for eGFR in the UK. This formula considers multiple factors that can influence creatinine production ...

Sawyer said CKD is defined as abnormal kidney structure and/or function that persists for three months or more, clinically manifested as a decline in the glomerular filtration rate (GFR), and ...

Cystatin C is emphasized as a preferred biomarker for accurate GFR measurement in CKD assessment. SGLT2i are recommended for CKD patients, regardless of diabetes status, for kidney and ...

If cystatin C is not available, a creatinine-based estimated glomerular filtration rate (eGFR) should be used to assess patients at risk for CKD. But if it is available, GFR should be estimated ...

with milder CKD (estimated glomerular filtration rate [eGFR] of 52.9 mL/min/1.73 m 2 ) in a 2-year time frame. The investigators noted the close connections between kidney and brain health.

Chronic kidney disease is defined as either kidney damage or GFR <60 mL/min/1.73m 2 for ≥3 months. Kidney damage is defined as pathologic abnormalities or markers of damage, including ...

People with stage 4 CKD have an eGFR of 15 to 29. These lower eGFR numbers indicate more severe kidney damage. A doctor may also test the urine for protein. Proteinuria, or too much protein in the ...

We further assessed for additive and multiplicative interactions 3 between levels of SU and inverted eGFR, on a standardized continuous scale per SD. Results We included 458,244 individuals (45% male, ...