The expectation maximization algorithm arises in many computational biology applications that involve probabilistic models. What is it good for, and how does it work?

EMrecon: An Expectation Maximization Based Image Reconstruction Framework for Emission Tomography Data. Thomas Kösters 3 Dirk Mannweiler 1,2 Klaus Schäfers 1 Frank Wübbeling 2. 1 European Institute ...

We developed an expectation–maximization (EM) algorithm to estimate the variance parameter of the prior distribution for each regression coefficient.