Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...
MC132 targeted p65 for ubiquitin-dependent proteasomal degradation by recruiting p65 to a host Cullin-5 (Cul-5)/BC complex, leading to effective suppression of NF-κB activity and thus benefiting virus ...
IFT172, the largest protein of the IFT complex, plays a crucial role in cilium formation ... uncovering a conserved U-box-like domain often found in E3 ubiquitin ligases. This domain exhibits ...
The ubiquitin proteasome system (UPS), a 76-amino acid complex, is a key regulator of protein catabolism ... CRL4 (Cullin-RING ubiquitin ligase) is an E3 ubiquitin ligase, composed of three subunits ...
second that the essential roles of TRAF6 in initiating innate immune signalling are independent of its E3 ligase activity; third that the HOIL-1 component of the Linear Ubiquitin Assembly Complex ...
Co. Ltd. has identified proteolysis targeting chimeras (PROTACs) comprising an E3 ubiquitin ligase binding moiety coupled to an androgen receptor targeting moiety through a linker acting as androgen ...
They found that cells missing FBXO31, a substrate adaptor for the SCF ubiquitin ligase complex, were unable to clear CTAPs. SCF ubiquitinates target proteins, delivering them to the proteasome ...
If we had a penny for all the Halo E3 demos to be made publicly available, we’d have two pennies (Microsoft) Last November, Microsoft and 343 Industries (or Halo Studios as it’s now called ...
These findings reveal how a small, intrinsically disordered protein with a simple architecture engages parallel channels of communication to reprogram a functionally complex ubiquitin ligase. The ...
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