These findings reveal how a small, intrinsically disordered protein with a simple architecture engages parallel channels of communication to reprogram a functionally complex ubiquitin ligase. The ...

The SCF (SKP1/CUL1/F-box protein) ubiquitin ligase complex plays a protective role against external stress, such as ultraviolet irradiation. The emergence of substrates activates SCF through ...

and attachment to the substrate protein by ubiquitin ligases (E3s). USP14 regulates PERIOD (PER) protein stability post-translationally in Drosophila via interaction with SLIMB, a protein involved ...

2 Priority Research Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute, University of Newcastle, Newcastle, New South Wales, Australia Correspondence to Professor Joerg ...