In a groundbreaking study published in Science, a research team led by Prof. YE Jian from the Institute of Microbiology of ...

In a study published in Science, a research team led by Prof. Ye Jian from the Institute of Microbiology of the Chinese ...

In a groundbreaking study published in Science, a research team led by Prof. YE Jian from the Institute of Microbiology of the Chinese Academy of ...

Neddylation is a post-translational modification that conjugates the NEDD8 protein to protein substrates, such as the cullins, which once neddylated join complex to form cullin-RING ubiquitin E3 ...

an E3 ligase that regulates T cell activation. Its drug candidate from protein degradation portfolio, NX-2127, is an orally available BTK degrader for the treatment of relapsed or refractory B ...

Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to ...

The recent CME and solar flare events occurred while the Sun was on a general downward trajectory in terms of activity after reaching the peak of Solar Cycle 25 in late 2024. NASA says that during ...

Less than a week since his victory at Milan-San Remo, Mathieu van der Poel (Alpecin-Deceuninck) once again stole the show at E3 Saxo Classic with a solo victory into Harelbeke. The Dutchman made ...

E3 ligases, such as SPOP and FBXO22, have been shown to ubiquitinate and degrade PD-L1, suggesting that their inhibition could enhance anti-tumor immune responses (11). Furthermore, the role of ...

Here we identify a novel signaling network centered on the E3 ubiquitin ligase praja2 that controls protein translation in GBM. Praja2 forms a multimeric complex with the RNA helicase DDX6, which ...