Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

In this review we discuss recent insights on the role of Cbl-B, Itch, and GRAIL in atherosclerosis and explore the therapeutic potential of these E3 ubiquitin ligases in cardiovascular medicine.

MC132 targeted p65 for ubiquitin-dependent proteasomal degradation by recruiting p65 to a host Cullin-5 (Cul-5)/BC complex, leading to effective suppression of NF-κB activity and thus benefiting virus ...

We determine the crystal structure of the C-terminal part of IFT172, uncovering a conserved U-box-like domain often found in E3 ubiquitin ligases. This domain exhibits ubiquitin-binding properties and ...

Reported a robust objective response rate of 75.5% from the Phase 1 study of NX-5948 in patients with relapsed/refractory CLL/SLL at the 66th American Society of Hematology Annual Meeting Received ...

PCSK9 inhibitors are being evaluated in HoFH and seem to be effective if there is residual receptor activity. E3-ubiquitin ligase inducible degrader of the LDL receptor has a similar function to ...

second that the essential roles of TRAF6 in initiating innate immune signalling are independent of its E3 ligase activity; third that the HOIL-1 component of the Linear Ubiquitin Assembly Complex ...

High levels of fat mass and obesity-associated protein (FTO) have been linked to increased tumor growth and resistance to ...

HSC70 enables a rapid stress response by alternately regulating the activities of SCF ubiquitin ligase and COP9 signalosome (CSN) in a substrate-dependent manner. HSC70 enhances CSN deneddylation ...