Seven students from among more than 300 entrants from the Loudoun County Public Schools Regional Science and Engineering Fair ...

Calcium-activated proteolysis by calpain is a candidate to participate in this form of pathology because it is activated under ischemic conditions and its activation results in the degradation of ...

AMX0114 is an antisense oligonucleotide that knocks down calpain-2, one of the key proteases driving axonal degeneration. Last month, the Phase I multiple ascending dose LUMINA trial of AMX ...

Amylyx began the Phase 1 LUMINA clinical trial of AMX0114, an investigational antisense oligonucleotide (ASO) targeting calpain-2, for people living with amyotrophic lateral sclerosis (ALS).

After just over a month of release, the Chinese mega-hit Ne Zha 2 has passed the $2 billion mark at the global box office. More precisely, it took just 33 days to achieve this unprecedented feat.

HDMI 2.2, eh? So what's that all about then? Well, it's the new standard for the High-Definition Multimedia Interface technology. The new and all-important '2.2' specification was revealed in ...

Growth and destruction are central components of the neuronal injury response. Injured axons that are capable of repair, including axons in the mammalian peripheral nervous system and in many ...

MMP-2 has also been suggested to degrade α-synuclein fibrils ... target to modulate protein aggregation and spreading in a two-pronged manner. Conversely, calpain cleavage was suggested to promote ...

Insulin is a paramount anabolic hormone that promotes energy-storage in adipose tissue, skeletal muscle and liver, and these responses are significantly attenuated in insulin resistance leading to ...

Disruption of interneuron NMDA receptors or pharmacological inhibition of calpain also led to increased KCC2 expression and defective radial dispersion of interneurons. Thus, although TCAs are not ...