For instance, CCR2/CCR5 inhibitors, such as PF-04136309 in pancreatic cancer, could disrupt TAM/Treg recruitment in ESCA, while CXCL8/CXCR2 blockade, trialed in CRC, may reduce MDSC/NET-mediated ...

An alternative strategy is to target cells, such as tumour-infiltrating macrophages, in the HCC tumour microenvironment. The CCL2/CCR2 axis is required for recruitment of monocytes/macrophages and is ...

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This study is important, and the findings add substantially to the evidence base regarding CCR5 antagonist drugs for neuroprotection and stroke management. The authors adhered to the expected ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Non-Commercial (NC): Only non-commercial uses of the work are permitted. Diffuse ...

These sites bind to coreceptor CCR5 or CXCR4 on the membrane of the host cell (center panel), an event that initiates steps that culminate in the fusion of the HIV envelope with the host cell ...

Engineered EVA-P974(F31A) inhibits receptor activation by multiple chemokines. Combined activation of CCR1 and CCR2 in THP-1 monocytes by the chemokine mixture CCL2+CCL5+CCL7 (orange) is fully ...

The CCR5-specific primers were adopted to distinguish between the CCR5 target locus and a highly similar site in CCR2 when local similarity searching in BLAST (Basic Local Alignment Search Tool; NCBI, ...

Although the role of CCR5 in immunity and in HIV infection has been studied widely, its role in neuronal plasticity, learning and memory is not understood. Here, we report that decreasing the function ...

†SNP rs number identity in the NCBI SNP database [143]. The SNP name in parentheses shown in the 'Polymorphism' column is as reported in the 'Association, yes/no' column. ‡MAF reported in the ...