Department of Bioengineering Technologies, Leijten Laboratory, Faculty of Science and Technology, Technical Medical Centre, University of Twente, Drienerlolaan 5, Enschede 7522NB, The Netherlands ...
Copyright held by the owner/author(s). This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International ...
An alternative strategy is to target cells, such as tumour-infiltrating macrophages, in the HCC tumour microenvironment. The CCL2/CCR2 axis is required for recruitment of monocytes/macrophages and is ...
CCR2-negative resident macrophage subsets with low expression of MHC-II are completely dependent on self-renewal proliferation. CCR2-negative resident macrophage subsets with high MHC-II expression ...
Mice lacking the archetypal monocyte chemokine CCL2, or mice in which the CCL2 receptor CCR2 was functionally inhibited, failed to exhibit recruitment in response to MIF. Given the central role of ...
We review here findings for the CCL2-CCR2 and CCL3-CCR5 chemokine-receptor systems that show the effects of these molecules on T cell differentiation. Possible roles of other chemokines and G ...
Frequency of mononuclear cell populations and chemokine receptor expression (CCR2, CCR4, CXCR3, CXCR4) were determined by flow cytometry. Chemokine levels of CCL2, CCL5, CXCL10 and CXCL11 were ...
C-C motif ligand 2 (CCL2), also known as monocytic chemotactic protein 1 (MCP-1), is an integral chemotactic factor which recruits macrophages for the immune response. Together with its receptors (e.g ...
Engineered EVA-P974(F31A) inhibits receptor activation by multiple chemokines. Combined activation of CCR1 and CCR2 in THP-1 monocytes by the chemokine mixture CCL2+CCL5+CCL7 (orange) is fully ...
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