CAR T-cell therapy tricks cancer cells with decoy, increases treatment efficiency in B-cell acute lymphoblastic leukemia
B-cell acute lymphoblastic leukemia (B-ALL) is a life-threatening and highly aggressive form of blood cancer. It is the most ...
eLife13d
Pu.1/Spi1 dosage controls the turnover and maintenance of microglia in zebrafish and mammals
Microglia are brain-resident macrophages playing pivotal roles in CNS development and homeostasis. Yet, the cellular and molecular basis governing microglia maintenance ...
Frontiers3y
Natural Product Erianin Inhibits Bladder Cancer Cell Growth by Inducing Ferroptosis via NRF2 Inactivation
The cells to be tested were collected in 100 μl 1×binding buffer placed in an ice box, and stained with FITC Annexin V and PI at room temperature out of Sun for 15 min. Then 200 μl 1×binding buffer ...
eLife4y
ATP and large signaling metabolites flux through caspase-activated Pannexin 1 channels
Pannexin 1 (Panx1) is a membrane channel implicated in numerous physiological and pathophysiological processes via its ability to support release of ATP and other cellular metabolites for local ...
Frontiers5y
Emerging Role of Migration and Invasion Enhancer 1 (MIEN1) in Cancer Progression and Metastasis
Migration and invasion enhancer 1 (MIEN1) is a membrane associated protein overexpressed ... Post-translationally modified MIEN1 interacts with Syk kinase and Annexin A2 protein; polymerizes G-actin ...