Combinatorial libraries are collections of chemical compounds, small molecules or macromolecules such as proteins, synthesized by combinatorial chemistry, in which multiple different combinations ...

The increasing bacterial resistance to known antibiotics has been causing concern in the population, since their therapeutic possibilities have been diminishing. 1 This has led to intensified research ...

Prof. John A. Katzenellenbogen’s career has spanned over 55 years and his work has led to 576 publications and 71 reviews and book chapters. His contributions to medicinal chemistry and bioorganic ...

The reaction of aryl halides in the presence of sodium in ... is a chemical reaction that involves the introduction of an acyl group onto an aromatic ring using a Lewis acid catalyst.

Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria ...

The N-acyl amino acids are a family of bioactive lipids with pleiotropic physiologic functions, including in energy homeostasis. Their endogenous levels are regulated by an extracellular mammalian ...

In this study, we demonstrate that the mitochondrial acyl carrier protein (ACP), which has a well-known role in FASII, plays an unexpected and evolutionarily conserved role in FeS biogenesis. ACP is a ...