gut.bmj8d
Single-cell omics in inflammatory bowel disease: recent insights and future clinical applications
Inflammatory bowel diseases (IBDs), which include ulcerative colitis (UC) and Crohn’s disease (CD), are chronic conditions ...
gut.bmj7d
Histology of subepithelial lesions (SELs) in the gastrointestinal tract-resected endoscopic: a database study of 4901 patients
Subepithelial lesions (SLEs) are often detected incidentally during endoscopic examination. They represent a heterogeneous ...
gut.bmj9d
Rewiring the altered tryptophan metabolism as a novel therapeutic strategy in inflammatory bowel diseases
Objective The extent to which tryptophan (Trp) metabolism alterations explain or influence the outcome of inflammatory bowel diseases (IBDs) is still unclear. However, several Trp metabolism ...
gut.bmj8d
Gut microbiota modulates COPD pathogenesis: role of anti-inflammatory Parabacteroides goldsteinii lipopolysaccharide
Correspondence to Dr Chia-Chen Lu, Department of Respiratory Therapy, Fu Jen Catholic University, New Taipei City, Taiwan; chiachen.lulu{at}gmail.com Objective Chronic obstructive pulmonary disease ...
gut.bmj9d
Precancerous nature of intestinal metaplasia with increased chance of conversion and accelerated DNA methylation
Objective The presence of intestinal metaplasia (IM) is a risk factor for gastric cancer. However, it is still controversial whether IM itself is precancerous or paracancerous. Here, we aimed to ...
gut.bmj8d
Time to progression of pancreatic ductal adenocarcinoma from low-to-high tumour stages
Correspondence to Dr Michael Goggins, Johns Hopkins Medical Institutions, Department of Pathology, 1550 Orleans Street, Baltimore, MD 21231, USA; mgoggins{at}jhmi.edu Objective Although pancreatic ...
gut.bmj11d
Guidelines on the management of abnormal liver blood tests
These updated guidelines on the management of abnormal liver blood tests have been commissioned by the Clinical Services and Standards Committee (CSSC) of the British Society of Gastroenterology (BSG) ...
gut.bmj9d
Angiogenin maintains gut microbe homeostasis by balancing α-Proteobacteria and Lachnospiraceae
Objective Antimicrobial peptides (AMPs) play essential roles in maintaining gut health and are associated with IBD. This study is to elucidate the effect of angiogenin (ANG), an intestine-secreted AMP ...
gut.bmj9d
Underdevelopment of the gut microbiota and bacteria species as non-invasive markers of prediction in children with autism spectrum disorder
Correspondence to Professor Siew C Ng, Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong; siewchienng{at}cuhk.edu.hk; Dr Ruth Chan, Applied Biology and Chemical ...
gut.bmj9d
Targeting the oncogenic m6A demethylase FTO suppresses tumourigenesis and potentiates immune response in hepatocellular carcinoma
Objective Fat mass and obesity-associated protein (FTO), an eraser of N 6-methyadenosine (m6A), plays oncogenic roles in various cancers. However, its role in hepatocellular carcinoma (HCC) is unclear ...
gut.bmj7d
Comprehensive single-cell analysis deciphered microenvironmental dynamics and immune regulator olfactomedin 4 in pathogenesis of gallbladder cancer
Objective Elucidating complex ecosystems and molecular features of gallbladder cancer (GBC) and benign gallbladder diseases is pivotal to proactive cancer prevention and optimal therapeutic ...
gut.bmj5d
Combining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade
Objective Investigating the effect of ferroptosis in the tumour microenvironment to identify combinatory therapy for liver cancer treatment. Design Glutathione peroxidase 4 (GPx4), which is considered ...