When Clooney and Wyle weren’t saving lives at Cook County General Hospital as Dr. Doug Ross and medical student John Carter ...

The actor looks back on his time playing Dr. John Carter on the NBC medical drama and his crossover with 'Friends' ...

Even though ER is credited as George Clooney’s breakout role ... he departed the medical drama for Hollywood, Clooney and his ER co-star Noah Wyle reunited for Fail Safe, a made-for-TV film ...

The star tells PEOPLE he didn't want to "risk ruining the legacy" of 'ER'Over 30 years after Noah Wyle first broke out ...

On one hand, the Noah ... saw Wyle’s Dr. Carter heading back into the action with Dr. Greene’s daughter starting her own ...

George Clooney is one of the most famous actors in the world, having starred in a string of hit movies over the years. Now he's shared his four favorite films of all time ...

During the early days of Noah Wyle's time on ER, he and costar George Clooney also guest-starred in an episode of Friends, making for a very cheeky crossover for the two popular NBC shows.

Related: Noah Wyle Recalls the Moment the Cast of ER Knew the Show Would Be a Hit — and How He Eluded George Clooney's Pranks The drama unfolds over one 15-hour shift inside a Pittsburgh-area em ...

From left: Jennifer Aniston, Courteney Cox, George Clooney and Noah Wyle on 'Friends' in 1996 ...