Thus, novel, effective therapies are required for treatment of this disease. Results We found that tumours in KRAS PTEN mice exhibit a remarkable dependence on mTOR signalling. In these tumours, mTOR ...

thereby suppressing the key step of de novo fatty acid synthesis (2); Dual inhibition of SREBP transcription factors through direct phosphorylation and mTORC1-dependent mechanisms, where SREBP-1c ...

Oxidative Stress: Neuropathy, Excitability, and Neurodegeneration.

This revised study provides valuable information on the single nucleus RNA sequencing transcriptome, pathways, and cell types in pig skeletal muscle in response to conjugated linoleic acid (CLA) ...

The acute glycolytic reprogramming of DC occurs within few minutes of TLR stimulation, independent of mammalian target of rapamycin (mTOR) but regulated by the PI3K/TBK1/IKKε/AKT signal axis. With the ...

Objective Dysregulated cellular metabolism is a distinct hallmark of human colorectal cancer (CRC). However, metabolic programme rewiring during tumour progression has yet to be fully understood.