In contrast, another downstream effecter of TGF-β/Smad signaling pathway, Smad2, exerts its renal protective role by counter-regulating the Smad3. Furthermore, recent studies demonstrated that Smad3 ...
TGF-β signals through both the canonical Smad pathway involving the receptor-regulated Smad proteins, SMAD2 and SMAD3, and the common-mediator Smad, SMAD4, as well as Smad-independent pathways, i.e., ...
It has recently been shown that the anticholinergic tiotropium may suppress TGF-β1-induced Smad2/4 activation in lung fibroblasts suggesting a crosstalk between TGF-β1 and muscarinic signalling.35 In ...
How cardiac cell fates are specified during heart development remains elusive. This study identifies a level-dependent role ...
The aim of this study was to delineate PI3K/mTOR signalling in response to TGF-β 1 stimulation of primary human lung fibroblasts (HLFs), and to investigate the role of this pathway in TGF-β 1 mediated ...
Department of Dermatology, Shenzhen People’s Hospital, the Second Clinical Medical College, Jinan University; the First Affiliated Hospital, Southern University of Science and Technology, Shenzhen ...
This progression corresponded to decreased collagen density, lowered numbers of SMA + fibroblasts and downregulation of the transforming growth factor beta (TGF-β)/SMAD signalling pathway in FAK ...
The authors demonstrate the valuable discovery that human CD29+/CD56+ myogenic progenitors can differentiate into tendon through the TGFβ pathway, addressing mouse and human interspecies differences ...
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