5 Alternative methods Besides trimming and winsorizing, there are other methods to deal with outliers in regression, such as transforming the data, using robust estimators, or adding dummy variables.

In symbolic regression with formal constraints, the conventional formulation of regression problem is extended with desired properties of the target model, like symmetry, monotonicity, or convexity.

A novel framework has recently been proposed for designing the molecular structure of chemical compounds with a desired chemical property using both artificial neural networks and mixed integer linear ...