This study presents a valuable advance for the analysis of gene expression variation at the level of individual cells by introducing a novel reference-free framework that can detect splicing, fusion, ...

Abstract: Pairwise statistical significance has been found to be quite accurate in identifying related sequences (homologs), which is a key step in numerous bioinformatics applications. However, it is ...

Computational biology and bioinformatics is an interdisciplinary field that develops and applies computational methods to analyse large collections of biological data, such as genetic sequences ...

Abstract: The exponential growth of genomic data presents a challenge to bioinformatics research. NCBI BLAST, a popular pairwise sequence alignment tool, does not scale with the hundreds of gigabytes ...

Part two presents examples of omics bioinformatics applications. Part three provides basic statistical analysis skills and programming skills needed to handle and analyze omics datasets.

Transdifferentiation of adventitial fibroblasts (AFs) into myofibroblasts plays a critical role during the vascular remodeling that occurs during atherosclerosis ...

Free software: 3-clause BSD license Documentation: https://www.hall-lab.org/clarite-python/. 1. Lucas AM, et al (2019) CLARITE facilitates the quality control and ...

Objectives: This investigation sought to explore the inhibitory impact of wogonin on prolactinoma and elucidate its underlying mechanisms through network pharmacology, molecular docking (MD), and ...

Everyone can learn to understand and leverage data - even you. The volume and complexity of data has exploded in recent years, creating new challenges for organizations that want to leverage its power ...