New gene switch activates with simple skin patch and could help treat diabetes
ETH researchers have developed a new gene switch that can be activated using a commercially available nitroglycerine patch ...
The EMBO Journal1d
LATS1/2 inactivation in the mammary epithelium drives the evolution of a tumor-associated niche
LATS1/2-inactivation and consequent nuclear YAP/TAZ hyperactivation in the mammary epithelium drives the development of a pro ...
BioPharma Dive1d
A brain biotech launches with Roche’s spare parts
Backed by Goldman Sachs, Novo Nordisk’s parent company and others, Newleos Therapeutics debuted Thursday with $94 million and ...
Gene editing approach sheds light on how mitochondria drive autophagy
Autophagy is the process by which cells digest and renew their internal structures, recycling damaged or malfunctioning ...
labiotech1d
Seven companies using metabolomics to decode biology
Discover seven companies operating in metabolomics, the field that could significantly boost precision medicine.
The EMBO Journal4d
A CRISPR-Cas9 screen reveals genetic determinants of the cellular response to decitabine
A temporally resolved CRISPR-Cas9 screen reveals DAC-induced DNA damage drives trans-cell cycle cytotoxicity that depends on ...
eLife4d
Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids
Due to proteostasis stress induced by aging or disease, misfolded proteins can form toxic intermediate species of aggregates and eventually mature into less toxic inclusion bodies (IBs). Here, using a ...