FMRP functions in RISC usually through interacting with Ago proteins, which repress FMRP target genes in an miRNA-dependent manner. 19, 25 For example, AGO1, which lacks endonuclease activity but ...

The recent discovery of microRNAs (miRNAs) took many by surprise because of their unorthodox features and widespread functions. These tiny, ∼22-nucleotide, RNAs control several pathways ...

The RISC complex helps both vsRNA and miRNA to bind to complementary sequences on target messenger RNAs. This alters the expression of the mRNA. In the case of the viroid, expression is abnormal ...

One strand of the mature miRNA duplex, known as the guide strand, is incorporated into the RNA-induced silencing complex (RISC). The RISC, guided by the miRNA, binds to complementary sequences in the ...

The miRNA is taken up into RISC and the target gene is degraded via different mechanisms, viz., interaction of miRNA with the 3′-UTR, or 5′-UTR or coding regions of the target gene [14,15] DNAzyme ...