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Expert Rev Ophthalmol. 2013;8(6):527-537. Protein kinase C-mediated contraction of RPE cells is stopped by an anti-PDGF antibody. Unfortunately, blocking PDGF is ineffective at suppressing PVR in ...

Figure 2 PDGF/PDGFRA signaling pathways and agent treatments. In PDGFRA mutaled GIST. PDGF isoforms bind to the related PDGFRs, initiate distinct receptor dimerization and phosphorylation, thereby ...

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Additional pathways known to be involved in the activation of PSCs such as FGF, PDGF or IGF-1 should also be interrogated as potential therapeutic targets in the GEMM.61 96 Furthermore, efforts aimed ...

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