As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

On Thursday, 27 March 2025, Enanta Pharmaceuticals (NASDAQ: ENTA) presented at the H.C. Wainwright 3rd Annual Autoimmune & Inflammatory Disease Virtual Conference. The company unveiled its strategic ...

Platelet-derived growth factor receptor A (PDGFRA) mutations occur in approximately 10–15% of gastrointestinal stromal tumors (GISTs). These tumors with PDGFRA mutations have a different pathogenesis, ...

7 Department of Ophthalmology and Visual Sciences, University of Michigan School of Medicine, Ann Arbor, Michigan, USA Correspondence to Dr Ronald Danis, Department of Ophthalmology and Visual ...

The authors have generated important resources such as a reference dataset of early primate development by utilizing single-cell transcriptomic technology together with induced pluripotent stem cells ...

Powder aims to feature only the best products and services. If you buy something via one of our links, we may earn a commission. The quiver of one that can do it all. It’s a concept that many ski, ...

Expert Rev Ophthalmol. 2013;8(6):527-537. Protein kinase C-mediated contraction of RPE cells is stopped by an anti-PDGF antibody. Unfortunately, blocking PDGF is ineffective at suppressing PVR in ...

Like most plasma membrane proteins, type I interferon (IFN) receptor (IFNAR) traffics from the outer surface to the inner compartments of the cell. Long considered as a passive means to simply control ...

3 Department of Medicine, Dept. of Pathology, and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York, USA Correspondence to Dr David Tuveson, Li Ka ...