Next, the effect of the cancer cells on the fibroblast's phenotype was analyzed (Figures 6D–F). MPR31.4 induced a decrease in PDGFR-β expression by about 1.5-fold, an increase in NG2 of about 5-fold ...
The authors have generated important resources such as a reference dataset of early primate development by utilizing single-cell transcriptomic technology together with induced pluripotent stem cells ...
Chair of Proteomics and Bioanalytics, School of Life Sciences, Technical University of Munich, 85354 Freising, Germany Chair of Proteomics and Bioanalytics, School of Life Sciences, Technical ...
This is followed by WDR5 (WD repeat domain 5)/MLL1 (lysine methyltransferase 2A)-mediated H3K4 trimethylation, ultimately activating pro-fibrotic TGF-β/SMAD3 signaling. 83 Accordingly, PRMT5 ...
The receptor tyrosine kinase (RTK) effect of pazopanib primarily results in blockade of VEGFR, PDGFR and c-Kit actions, but other RTKs are affected to a lesser extent and myriad downstream cascade ...
Vascular pathologies are prevalent in a broad spectrum of diseases, necessitating a deeper understanding of vascular biology, particularly in overcoming the oxygen and nutrient diffusion limit in ...
A real-time cell analysis system mainly based on a wound-healing assay and intracellular phosphorylation of human FLS pointed towards the effectiveness of the inhibitors of PDGFR, Akt, PI3K or GSK-3 ...
Beta-alanine is an amino acid popular in supplements because it may help improve athletic performance and muscle recovery. Made in the liver and found in some foods, beta-alanine is needed to produce ...
Institute of Organic Chemistry, University of Vienna, Währinger Straße 38, 1090 Vienna, Austria ...
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