In addition, platelet-derived growth factor receptor α-expressing Gdf5 lineage cells were found to ... of human FLS pointed towards the effectiveness of the inhibitors of PDGFR, Akt, PI3K or GSK-3 in ...

The authors have generated important resources such as a reference dataset of early primate development by utilizing single-cell transcriptomic technology together with induced pluripotent stem cells ...

Expert Rev Hematol. 2011;4(5):551-562. In addition, there are several trials currently examining the combination of bortezomib and histone deacetylase inhibitors (HDACi) or 5-azacitidine in the ...

Cardiac fibrosis, a hallmark of heart failure and various cardiomyopathies, represents a complex pathological process that has long challenged therapeutic intervention. High-throughput omics ...

Expert Rev Neurother. 2008;8(10):1457-1473.

The receptor tyrosine kinase (RTK) effect of pazopanib primarily results in blockade of VEGFR, PDGFR and c-Kit actions, but other RTKs are affected to a lesser extent and myriad downstream cascade ...

Introduction: Epilepsy is common in gliomas, particularly astrocytomas, even in patients who have undergone total tumor resection. Resistance to antiseizure drugs presents a significant challenge in ...

IFNAR2 intracellular trafficking has long remained poorly characterized. A first study measured unchanged IFNAR2 levels at the PM during IFN-α stimulation while IFNAR1 was efficiently degraded (168).